Shock‐Like Sensations During Venlafaxine Withdrawal

Electric shock‐like sensations may occur after cessation of treatment with serotonin selective reuptake inhibitors but are reported in the literature only rarely with discontinuation of venlafaxine. Two patients experienced severe shock‐like sensations during venlafaxine withdrawal. For both patient...

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Bibliographic Details
Published in:Pharmacotherapy 2003-05, Vol.23 (5), p.678-681
Main Authors: Reeves, Roy R., Mack, James E., Beddingfield, John J.
Format: Article
Language:English
Subjects:
Adult
Antidepressive Agents, Second-Generation - administration & dosage
Antidepressive Agents, Second-Generation - adverse effects
Biological and medical sciences
Cyclohexanols - administration & dosage
Cyclohexanols - adverse effects
Dose-Response Relationship, Drug
Female
Humans
Male
Medical sciences
Middle Aged
Sensation Disorders - chemically induced
Substance Withdrawal Syndrome - etiology
Venlafaxine Hydrochloride
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Summary:Electric shock‐like sensations may occur after cessation of treatment with serotonin selective reuptake inhibitors but are reported in the literature only rarely with discontinuation of venlafaxine. Two patients experienced severe shock‐like sensations during venlafaxine withdrawal. For both patients symptoms occurred with lowering of the dosage and persisted for 5 days after complete discontinuation of the drug. These sensations may represent significant alteration of neuronal activity in the central nervous system.
ISSN:0277-0008
1875-9114
DOI:10.1592/phco.23.5.678.32198