Lepirudin Anticoagulation for Heparin‐Induced Thrombocytopenia After Cardiac Surgery in a Pediatric Patient

A 21‐month‐old boy received anticoagulation with lepirudin for heparin‐induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the success...

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Bibliographic Details
Published in:Pharmacotherapy 2006-05, Vol.26 (5), p.709-712
Main Authors: Knoderer, Chad A., Knoderer, Holly M., Turrentine, Mark W., Kumar, Manjusha
Format: Article
Language:English
Subjects:
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
anticoagulation
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Cardiac Surgical Procedures
Child, Preschool
Echocardiography
Extracorporeal Membrane Oxygenation
Fontan Procedure
Heparin - adverse effects
heparin‐induced thrombocytopenia
Hirudins
HIT
Humans
Hypoplastic Left Heart Syndrome - complications
Hypoplastic Left Heart Syndrome - surgery
lepirudin
Male
Medical sciences
pediatric
Pharmacology. Drug treatments
Platelet Count
Postoperative Complications - drug therapy
Recombinant Proteins - therapeutic use
Thrombocytopenia - chemically induced
Thrombocytopenia - drug therapy
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Summary:A 21‐month‐old boy received anticoagulation with lepirudin for heparin‐induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.
ISSN:0277-0008
1875-9114
DOI:10.1592/phco.26.5.709