Controversy and Conflict in the Treatment of Acute Decompensated Heart Failure: Nesiritide as Evidence-Based Treatment

Acute decompensated heart failure poses a complex clinical challenge for the health care community. Evolving concepts of the pathophysiology and lack of consensus on appropriate outcome measures for drug approval underlie some of the current controversies about nesiritide. We outline the major contr...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacotherapy 2007-05, Vol.27 (5), p.619-625
Main Authors: Munger, Mark A., Ng, Tien M. H., Van Tassell, Benjamin W.
Format: Article
Language:English
Subjects:
acute decompensated heart failure
Acute Disease
ADHF
Biological and medical sciences
cardiology
Cardiology. Vascular system
Evidence-Based Medicine
evidence-based treatment
Heart
Heart Failure - drug therapy
Heart Failure - mortality
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Medical sciences
Natriuretic Agents - administration & dosage
Natriuretic Agents - adverse effects
Natriuretic Agents - pharmacology
Natriuretic Agents - therapeutic use
Natriuretic Peptide, Brain - administration & dosage
Natriuretic Peptide, Brain - adverse effects
Natriuretic Peptide, Brain - pharmacology
Natriuretic Peptide, Brain - therapeutic use
nesiritide
Outcome Assessment (Health Care) - methods
Patient Selection
Pharmacology. Drug treatments
Practice Guidelines as Topic
Renal Insufficiency
safety
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acute decompensated heart failure poses a complex clinical challenge for the health care community. Evolving concepts of the pathophysiology and lack of consensus on appropriate outcome measures for drug approval underlie some of the current controversies about nesiritide. We outline the major controversies from the viewpoint that nesiritide should continue to be used judiciously by following its package insert recommendations and the Heart Failure Society of America's 2006 Comprehensive Heart Failure Practice Guidelines.
ISSN:0277-0008
1875-9114
DOI:10.1592/phco.27.5.619