Porphyrin-Mediated Boron Neutron Capture Therapy: A Preclinical Evaluation of the Response of the Oral Mucosa

Morris, G. M., Coderre, J. A., Micca, P. L., Nawrocky, M. M., Hopewell, J. W. and Miura, M. Porphyrin-Mediated Boron Neutron Capture Therapy: A Preclinical Evaluation of the Response of the Oral Mucosa. Radiat. Res. 163, 72– 78 (2005). Preclinical studies are in progress to determine the potential o...

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Bibliographic Details
Published in:Radiation research 2005-01, Vol.163 (1), p.72-78
Main Authors: Morris, G. M., Coderre, J. A., Micca, P. L., Nawrocky, M. M., Hopewell, J. W., Miura, M.
Format: Article
Language:English
Subjects:
Animals
Blood
Body Burden
Boron
Boron neutron capture therapy
Boron Neutron Capture Therapy - adverse effects
Boron Neutron Capture Therapy - methods
Dose-Response Relationship, Radiation
Drug Evaluation, Preclinical
Epithelium
Female
Irradiation
Lethal Dose 50
Metalloporphyrins - adverse effects
Metalloporphyrins - therapeutic use
Mouth
Mouth Mucosa - pathology
Mouth Mucosa - radiation effects
Oral Ulcer - etiology
Oral Ulcer - pathology
Radiation dosage
Radiation Injuries - etiology
Radiation Injuries - pathology
Radiotherapy
Radiotherapy Dosage
Rats
Rats, Inbred F344
REGULAR ARTICLES
Relative Biological Effectiveness
Thermal neutrons
Tissue Distribution
Tongue
Treatment Outcome
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Summary:Morris, G. M., Coderre, J. A., Micca, P. L., Nawrocky, M. M., Hopewell, J. W. and Miura, M. Porphyrin-Mediated Boron Neutron Capture Therapy: A Preclinical Evaluation of the Response of the Oral Mucosa. Radiat. Res. 163, 72– 78 (2005). Preclinical studies are in progress to determine the potential of boron neutron capture therapy (BNCT) for the treatment of carcinomas of the head and neck. Recently, it has been demonstrated that various boronated porphyrins can target a variety of tumor types. Of the porphyrins evaluated so far, copper tetracarboranylphenyl porphyrin (CuTCPH) is potentially a strong candidate for clinical use. In the present investigation, the response of the oral mucosa to CuTCPH-mediated boron neutron capture (BNC) irradiation was assessed using the ventral surface of the tongue of adult male Fischer 344 rats, a standard rodent model. CuTCPH was administered by intravenous infusion, at a dose of 200 mg/kg body weight, over a 48-h period. Three days after the end of the administration of CuTCPH, biodistribution studies indicated very low levels of boron (
ISSN:0033-7587
1938-5404
DOI:10.1667/RR3272