Prognostic value of a level of decrease in mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR) for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: an observational study

• Published in: Biomolecules & biomedicine 2023-05
• Main Authors: Bećirović, Emir, Ljuca, Kenana, Bećirović, Minela, Ljuca, Nadina, Bajrić, Mugdim, Brkić, Ammar, Ljuca, Farid
• Format: Article
• Language: English
• ISSN: 2831-0896; 2831-090X
• DOI: 10.17305/bb.2023.9178

The current study aimed to explore whether the level of decrease in platelet distribution width (PDW), platelet large cell ratio (P-LCR), and mean platelet volume (MPV) has prognostic value for major adverse cardiovascular events (MACEs) in acute myocardial infarction without ST-segment elevation (NSTEMI) treated by clopidogrel. In this prospective observational cohort study, PDW, P-LCR, and MPV were determined on admission at the hospital and 24 hours after clopidogrel treatment in 170 non-STEMI patients. MACEs were assessed over a one-year follow-up period. Using the Cox regression test, a decrease in PDW showed a significant association with the incidence of MACEs (OR 0.82, 95% CI 0.66-0.99, p=0.049) and overall survival rate (OR 0.95, 95% CI=0.91-0.99, p=0.016). Patients with a decrease in PDW