Recent Advancement in the development of hybridization chain reaction-based electrochemiluminescence biosensors

Electrochemiluminescence (ECL) biosensors have been widely used in bioassays due to their high sensitivity, fast response, simple equipment and low cost. Signal amplification is an important means to improve the sensitivity of ECL biosensors. The common enhancement strategies include DNA amplificati...

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Bibliographic Details
Published in:International journal of electrochemical science 2022-06, Vol.17 (6), p.220650, Article 220650
Main Authors: Sun, Ting, Du, Jia, Li, Zhuo, Zhao, Feng
Format: Article
Language:English
Subjects:
electrochemiluminescence biosensor
Hybridization chain reaction
nanomaterials
signal amplification
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Summary:Electrochemiluminescence (ECL) biosensors have been widely used in bioassays due to their high sensitivity, fast response, simple equipment and low cost. Signal amplification is an important means to improve the sensitivity of ECL biosensors. The common enhancement strategies include DNA amplification, enzyme-assisted signal enhancement, nanomaterials-based amplification, and the application of redox-active probes and luminophores. Among them, hybridization chain reaction (HCR) shows simple experiment operation and high amplification efficiency, which can be integrated with various detection technologies for signal enhancement. This paper mainly summarizes the application of HCR amplification in the design of ECL biosensors.
ISSN:1452-3981
1452-3981
DOI:10.20964/2022.06.35