A highly sensitive electrochemiluminescence sensor based on antimony tin oxide/TiO2 for detection of gastrin-releasing peptide (ProGRP)

Progastrin-releasing peptide (ProGRP) is a highly reliable, specific and sensitive tumor marker for small cell lung cancer, thus the measurement of ProGRP levels can realize the diagnosis, prediction of prognosis and treatment monitoring of small cell lung cancer. Aptamer can bind specifically to pr...

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Bibliographic Details
Published in:International journal of electrochemical science 2022-11, Vol.17 (11), p.221188, Article 221188
Main Authors: Wu, Qinghong, Zheng, Wenjuan
Format: Article
Language:English
Subjects:
Ag nanoparticle
Aptasensor
Electrochemical luminescence
Nano antimony tin oxide
ProGRP
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Summary:Progastrin-releasing peptide (ProGRP) is a highly reliable, specific and sensitive tumor marker for small cell lung cancer, thus the measurement of ProGRP levels can realize the diagnosis, prediction of prognosis and treatment monitoring of small cell lung cancer. Aptamer can bind specifically to proteins or other substances with high selectivity and affinity, and it has more stable chemical properties than antibodies. In this work, an electrochemiluminescent aptamer sensor was constructed for ProGRP detection based on AgNPs composites. For the sensor, luminol was used as the luminol, hydrogen peroxide was used as the co-reaction reagent, and titanium dioxide and AgNPs were used to enhance the luminescence, which improved the luminescence intensity and sensitivity of the sensor. The linear detection range was 10 fg/mL-12 ng/mL with a detection limit of 1.3 fg/mL under optimal experimental conditions.
ISSN:1452-3981
1452-3981
DOI:10.20964/2022.11.78