VALIDATION OF ETHNOPHARMACOLOGICAL USE AS ANTI-INFLAMMATORY OF A DECOCTION FROM ANNONA MURICATA LEAVES

Background: Through this work we evaluated the potential of the aqueous extract of Annona muricata L. leaves (AMAEL) to treat inflammatory conditions. The use of decoction or infusion of this important medicinal resource is still not scientifically validated. Methods: Different doses of AMAEL were a...

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Bibliographic Details
Published in:African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2015-07, Vol.12 (4), p.14-20
Main Authors: Quilez, A.M, Montserrat-de la Paz, S, De la Puerta, R, Fernández-Arche, M.A, García-Giménez, M.D
Format: Article
Language:English
Subjects:
aqueous extract
ethnomedicinal use
inflammation
myeloperoxidase
nitric oxide
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Summary:Background: Through this work we evaluated the potential of the aqueous extract of Annona muricata L. leaves (AMAEL) to treat inflammatory conditions. The use of decoction or infusion of this important medicinal resource is still not scientifically validated. Methods: Different doses of AMAEL were assayed in carrageenan-induced inflammation and tetradecanoylphorbol acetate (TPA)-induced edema in mice, myeloperoxidase activity (MPO) in inflamed tissue, MPO released by A-23187-stimulated rat neutrophils and nitric oxide released by murine macrophages. Acute oral toxicity and cell viability of murine macrophages were also tested. Results: A single dose of 250, 500 and 1000 mg/kg of AMAEL did not show any symptoms associated with toxicity in vivo and the viability of murine macrophages was of 100% at the assayed doses. AMAEL at 250mg/kg and 500mg/kg exerted a significant edema reduction in the carrageenan inflammation model (26.82±0.02%, p
ISSN:0189-6016
2505-0044
DOI:10.21010/ajtcam.v12i4.3