REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDY OF SUPLATAST TOSILATE (IPD-1151T) (2) : Teratological Study in Rats by Oral Administration

• Published in: Journal of toxicological sciences 1992/05/11, Vol.17(SupplementII), pp.155-174
• Main Authors: YAMAKITA, Osamu, SHINOMIYA, Mitsuhiro, KOIDA, Masahiro, KATAYAMA, Shigenori, IKEBUCHI, Kazuya, YOSHIDA, Ryouichi
• Format: Article
• Language: eng ; jpn
• Subjects: Abnormalities, Drug-Induced; Administration, Oral; Animals; Arylsulfonates - administration & dosage; Arylsulfonates - toxicity; Body Weight - drug effects; Drug Evaluation, Preclinical; Embryonic and Fetal Development - drug effects; Female; Fetus - drug effects; Histamine Antagonists - administration & dosage; Histamine Antagonists - toxicity; Male; Pregnancy; Rats; Rats, Inbred Strains; Reproduction - drug effects; Sulfonium Compounds - administration & dosage; Sulfonium Compounds - toxicity; Wistar rats
• ISSN: 0388-1350; 1880-3989
• DOI: 10.2131/jts.17.SupplementII_155

A teratological study of suplatast tosilate (IPD-1151T), a new anti-allergic agent which has a suppressive action on IgE antibody formation, was conducted with pregnant Wistar rats. Dosage levels of IPD-1151T 0, 300, 900 and 2700 mg/kg/day were administered to dams orally by gavage on days 7 through 17 of gestation. Two-thirds of dams per group was caesarean-sectioned on day 20 of gestation and their fetuses were removed for examination of external, visceral and skeletal anomalies. The remaining one-third was allowed to deliver naturally. F1 neonates were examined developmental, functional and behavioral parameters and reproductive abilities. The results were as follows: 1. Toxicities on F0 dams in the 2700 mg/kg/day group were salivation, piloerection, and decreases in body weight and food consumption. Seven animals (19.4%) showed severe toxicity and were dead. Toxicity in the 900 mg/kg/day group was a slight decrease in food consumption. The dosage level of 300 mg/kg/day was non-toxic. 2. Toxicities on F1 fetuses in the 2700 mg/kg/day group were a decrease in body weight and an increase in visceral anomalies (main one was ventricular septal defect that might be related to developmental retardation). No toxicities were seen in the 300 and 900 mg/kg/day. 3. In F1 neonates, suppressions of body weight were observed clearly in the male and female 2700 mg/kg/day and slightly in the male 900 mg/kg/day groups. But no changes in parameters of development, function, behavior or reproductive ability were seen in any dosed groups. It was suggested that no effective dose levels of IPD-1151T were 300 mg/kg/day for F0 dams and F1 neonates, and 900 mg/kg/day for F1 fetuses.