MUTAGENICITY AND DOMINANT LETHAL TEST OF KOJIC ACID : Ames test, forward mutation test in cultured chinese hamster cells and dominant lethal test in mice

The mutagenicity of kojic acid was studied by means of reversion mutation test in bacteria (Ames test), forward mutation test in cultured Chinese hamster cells and dominant lethal test in mice. A positive result was obtained only in Ames test (TA 98, 1535 and 100) which was not modified by the prese...

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Bibliographic Details
Published in:Journal of toxicological sciences 1982/11/25, Vol.7(4), pp.255-262
Main Authors: SHIBUYA, Tohru, MUROTA, Tetsuro, SAKAMOTO, Kyoko, IWAHARA, Shigeo, IKENO, Migiwa
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Cricetinae
Cricetulus
dominant lethal test
Female
Genes, Dominant - drug effects
Genes, Lethal - drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mutagenicity Tests
Mutagens
Pyrans - toxicity
Pyrones - toxicity
Salmonella - genetics
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Description
Summary:The mutagenicity of kojic acid was studied by means of reversion mutation test in bacteria (Ames test), forward mutation test in cultured Chinese hamster cells and dominant lethal test in mice. A positive result was obtained only in Ames test (TA 98, 1535 and 100) which was not modified by the presence of S-9 fraction. Thus, it is concluded that although kojic acid is a weak mutagen in bacteria, it is nonmutagenic in eukaryotic systems either in vivo or in vitro.
ISSN:0388-1350
1880-3989
DOI:10.2131/jts.7.255