Association between -455G/A and fibrinogen in a Chinese population

• Published in: Acta Cardiologica 2009-06, Vol.64 (3), p.357-361
• Main Authors: Sun, Aijun, Ma, Huili, Xu, Danling, Wang, Ying, Liu, Ming, Xu, Lei, Chen, Jilin, Hu, Taohong, Wang, Zhen, Wang, Keqiang, Zou, Yunzeng, Huang, Wei, Ge, Junbo
• Format: Article
• Language: English
• Subjects: 455G/A polymorphism; acute coronary syndrome; Acute Coronary Syndrome - blood; Acute Coronary Syndrome - genetics; Alleles; Angina Pectoris - blood; Angina Pectoris - genetics; Case-Control Studies; China - epidemiology; Coronary Artery Disease - blood; Coronary Artery Disease - epidemiology; Coronary Artery Disease - genetics; Female; Fibrinogen - genetics; Fibrinogen - metabolism; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Risk Assessment; stable angina pectoris; Statistics as Topic; β-fibrinogen gene
• ISSN: 0001-5385; 0373-7934; 0001-5385
• DOI: 10.2143/AC.64.3.2038022

Objective - The aim of the study was to evaluate the association between b-fibrinogen gene - 455G/A polymorphism and the plasma fibrinogen level in Chinese patients with different subtypes of coronary heart disease (CHD). Methods and results - We investigated b-fibrinogen gene -455G/A polymorphism and plasma fibrinogen level in non-CHD control subjects (n=466) and CHD patients (n=1,019) including patients with stable angina pectoris (SAP) (n=674), and acute coronary syndrome (ACS) (n=345). Increased plasma fibrinogen levels were observed in the CHD groups compared with the control subjects (ACS: 380.92±92.35mg/dl, SAP: 352.49±94.89mg/dl, control: 311.72±87.09* mg/dl,* P