Antihypertensive effect of manidipine

Manidipine is a lipophilic, third-generation, highly vasoselective, dihydropyridine (DHP) calcium channel antagonist, which, when given on a once-daily basis, effectively reduces blood pressure (BP) in patients with mild-to-moderate essential hypertension. Manidipine has a gradual onset and a long d...

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Bibliographic Details
Published in:Drugs (Basel) 2005, Vol.65 (Suppl 2), p.11-19
Main Authors: ROCA-CUSACHS, Alex, TRIPOSKIADIS, Filippos
Format: Article
Language:English
Subjects:
Age Factors
Aged
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antihypertensive agents
Antihypertensive Agents - adverse effects
Antihypertensive Agents - therapeutic use
Biological and medical sciences
Calcium Channel Blockers - therapeutic use
Cardiovascular system
Diabetes Mellitus, Type 2 - drug therapy
Dihydropyridines - adverse effects
Dihydropyridines - therapeutic use
Female
Humans
Hypertension - drug therapy
Kidney Diseases - drug therapy
Male
Medical sciences
Pharmacology. Drug treatments
Randomized Controlled Trials as Topic
Syndrome
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Summary:Manidipine is a lipophilic, third-generation, highly vasoselective, dihydropyridine (DHP) calcium channel antagonist, which, when given on a once-daily basis, effectively reduces blood pressure (BP) in patients with mild-to-moderate essential hypertension. Manidipine has a gradual onset and a long duration of action, effectively maintaining reduced BP levels throughout the 24-hour dosing period, and is effective in the long term with no evidence of intolerance. The BP-lowering capacity of manidipine is similar to that of other established DHPs and of angiotensin-converting enzyme inhibitors. Diabetic patients and very elderly patients with mild-to-moderate hypertension also respond favourably to treatment with manidipine. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension.
ISSN:0012-6667
1179-1950
DOI:10.2165/00003495-200565002-00003