Genotoxicity Induced by Dental Materials: A Comprehensive Review

Genotoxicity is the capacity of an agent to produce damage in the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, evaluation of genotoxicity induced by dental materials is necessary for elucidating the true health risks to patients and prof...

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Bibliographic Details
Published in:Anticancer research 2017-08, Vol.37 (8), p.4017
Main Authors: Ribeiro, Daniel Araki, Yujra, Veronica Quispe, DE Moura, Carolina Foot Gomes, Handan, Bianca Andrade, DE Barros Viana, Milena, Yamauchi, Liria Yuri, Castelo, Paula Midori, Aguiar, Jr, Odair
Format: Article
Language:English
Subjects:
Carcinogenesis - drug effects
Carcinogenesis - genetics
Dental Materials - adverse effects
Dental Materials - therapeutic use
DNA Damage - drug effects
DNA Damage - genetics
Humans
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Summary:Genotoxicity is the capacity of an agent to produce damage in the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, evaluation of genotoxicity induced by dental materials is necessary for elucidating the true health risks to patients and professionals. The purpose of this article was to provide a comprehensive review of genotoxicity induced by dental materials. All published data showed some evidence of genotoxicity, especially related to dental bleaching, restorative materials and endodontic compounds. Certainly, such information will be added to that already established for regulatory purposes as a safe way to promote oral healthcare and prevent oral carcinogenesis.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11786