Preoperative High Neutrophil-to-Lymphocyte Ratio Is Associated with High-grade Bladder Cancer

To evaluate the correlation between the neutrophil-to-lymphocyte ratio (NLR) and histopathological characteristics of bladder cancer. A retrospective analysis was performed on a cohort of patients (n=302) who were diagnosed with bladder cancer and underwent transurethral resection of bladder tumor o...

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Bibliographic Details
Published in:Anticancer research 2017-08, Vol.37 (8), p.4659
Main Authors: Tang, Xingxing, Wang, Shuo, An, Chao, Du, Peng, Yang, Yong
Format: Article
Language:English
Subjects:
Aged
Female
Humans
Leukocyte Count
Lymphocytes
Male
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Neutrophils
Preoperative Period
Retrospective Studies
Urinary Bladder Neoplasms - blood
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
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Summary:To evaluate the correlation between the neutrophil-to-lymphocyte ratio (NLR) and histopathological characteristics of bladder cancer. A retrospective analysis was performed on a cohort of patients (n=302) who were diagnosed with bladder cancer and underwent transurethral resection of bladder tumor or cystectomy between 2009 and 2016. The pathological outcomes were compared between patients with low NLR and those with high NLR with a cut-off value of 2.5, and a logistic regression analysis was performed to find potential predictors of pathological tumor outcomes. Patients with high-grade disease had significantly higher NLRs compared to those with low-grade disease (median NLR=4.42 vs. 3.42, p
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11869