Uptake of 18 F-Fluorodeoxyglucose in Major Salivary Gland Cancer Predicts Survival Adjusting for Pathological Stage

To investigate whether F-fluorodeoxyglucose uptake is associated with overall survival in patients with major salivary gland cancer using univariate and multivariate analyses after adjusting for pathological stage (eighth edition of the International Union Against Cancer). A total of 32 patients wit...

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Bibliographic Details
Published in:Anticancer research 2019-02, Vol.39 (2), p.1043-1049
Main Authors: Suzuki, Hidenori, Tamaki, Tsuneo, Nishio, Masami, Terada, Hoshino, Nishikawa, Daisuke, Koide, Yusuke, Beppu, Shintaro, Hanai, Nobuhiro
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Fluorodeoxyglucose F18 - metabolism
Humans
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Positron Emission Tomography Computed Tomography
Preoperative Period
Prognosis
Proportional Hazards Models
Radiopharmaceuticals - metabolism
Salivary Gland Neoplasms - diagnostic imaging
Salivary Gland Neoplasms - mortality
Salivary Gland Neoplasms - surgery
Survival Analysis
Treatment Outcome
Tumor Burden
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Summary:To investigate whether F-fluorodeoxyglucose uptake is associated with overall survival in patients with major salivary gland cancer using univariate and multivariate analyses after adjusting for pathological stage (eighth edition of the International Union Against Cancer). A total of 32 patients with major salivary gland cancer treated with curative surgery were enrolled. Parameters for F-fluorodeoxyglucose uptake were assessed by positron-emission tomography combined with computed tomography. Using univariate and multivariate analyses after adjusting for pathological stage, a maximum standardized uptake value ≥26, peak standardized uptake value ≥20.3, metabolic tumor volume ≥9.7, and total lesion glycolysis ≥263 were significantly correlated with shorter overall survival. Parameters of F-fluorodeoxyglucose uptake in major salivary gland cancer are predictive of overall survival after adjusting for the pathological stage.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13211