Fucoxanthin Prevents Colorectal Cancer Development in Dextran Sodium Sulfate-treated Apc Min/+ Mice

• Published in: Anticancer research 2021-03, Vol.41 (3), p.1299-1305
• Main Authors: Terasaki, Masaru, Hamoya, Takahiro, Kubota, Atsuhito, Kojima, Hiroyuki, Tanaka, Takuji, Maeda, Hayato, Miyashita, Kazuo, Mutoh, Michihiro
• Format: Article
• Language: English
• Subjects: Adenomatous Polyposis Coli - complications; Animals; Anticarcinogenic Agents - administration & dosage; Colorectal Neoplasms - chemically induced; Colorectal Neoplasms - prevention & control; Cyclin D1 - analysis; Cyclin D1 - physiology; Dextran Sulfate; Disease Models, Animal; Male; Mice; Xanthophylls - administration & dosage
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.14887

A xanthophyll of fucoxanthin (Fx) is a potential chemopreventive agent. Familial adenomatous polyposis (FAP) is an inherited disease that is associated with a high risk of developing colorectal cancer. However, it remains unclear whether Fx can modify colorectal tumorigenesis in Apc mice, a model mouse for human FAP. We investigated the chemopreventive effect of Fx in dextran sodium sulfate (DSS)-treated Apc mice. Administration of Fx in the diet for 5 weeks significantly suppressed the number of colorectal adenocarcinomas in DSS-treated male Apc mice, although the treatment did not affect the occurrence of colorectal dysplastic crypts and adenoma in the mice. In addition, Fx down-regulated cyclin D1 expression (0.6-fold) in colorectal mucosa of Apc mice when compared with that of the control mice. Fx possesses chemopreventive potential against progression of colorectal carcinogenesis in Apc mice that receive inflammatory stimuli.