EXPERIMENTAL EVALUATION OF THE ANTI-ULCER ACTIVITY OF GRAPE (VITIS VINIFERA) SEED EXTRACT IN WISTAR ALBINO RATS AGAINST HYDROCHLORIC ACID – ETHANOL INDUCED ULCER MODEL

• Published in: Asian journal of pharmaceutical and clinical research 2016-11, Vol.9 (6), p.346
• Main Authors: Ingale, Anand M, Pinnelli, Dr. Venkata Bharatkumar, Rajendran, Dr. Vijaya
• Format: Article
• Language: English
• ISSN: 0974-2441; 0974-2441
• DOI: 10.22159/ajpcr.2016.v9i6.14999

Background:Herbal products are finding increasing demand in the treatment of Peptic ulcer, on account of their better safety and efficacy.Objectives:To evaluate the anti-ulcer activity of ethanolic extract of seeds of Vitis Vinifera in Wistar albino rats.Methods:The ethanolic extract of Vitis Vinifera was investigated for its anti-ulcer activity in rats against HCl – Ethanol induced ulcer model. The antiulcer activity was assessed by determining and comparing gastric volume, pH, free and total acidity; ulcer number and its inhibition, ulcer severity and ulcer index.Results:A significant antiulcer activity was observed. The grape seed 100mg/kg group showed significant [p < 0.05] reduction in ulcer number 30.00 ± 3.23 as compared to the control. The grape seed 200mg/kg showed significant [p < 0.05] reduction in ulcer number 27.33 ± 2.97, free acidity 20.00 ± 2.26, and gastric lesion18.00 ± 2.96 as compared to the control.Conclusion:This present study indicates that Vitis vinifera seed extract has potential anti ulcer activity in the model tested. Keywords: Vitis vinifera, Anti-ulcer, Ethanol, Free acidity, Total acidity