FORMULATION AND EVALUATION OF RED PALM OLEIN NANOEMULSION

Objective: The objective of this study is to formulate and evaluate the red palm olein (RPO) nanoemulsion using spontaneous emulsification method.Methods: Nanoemulsion formulated by spontaneous emulsification method using the comparison of surfactant (tween 80) and cosurfactant (sorbitol) concentrat...

Full description

Saved in:
Bibliographic Details
Published in:Asian journal of pharmaceutical and clinical research 2018-09, Vol.11 (9), p.237
Main Authors: Sari, Febia, Sinaga, Kasmirul Ramlan, Siahaan, Donald
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: The objective of this study is to formulate and evaluate the red palm olein (RPO) nanoemulsion using spontaneous emulsification method.Methods: Nanoemulsion formulated by spontaneous emulsification method using the comparison of surfactant (tween 80) and cosurfactant (sorbitol) concentration with the variation of RPO concentration. Evaluation of the stability of the nanoemulsion preparation includes centrifugation test, viscosity, pH, organoleptic observation (odor, color, clarity, and phase separation), and particle size measurement during 12 weeks storage at room temperature.Result: The results showed that all nanoemulsion preparations were transparent yellow, characteristic odor, type weights 1.0166–1.0641 g/ml, and stable for 12 weeks storage at room temperature. The smallest particle size was produced by the nanoemulsion preparation in a formula of the concentration of 5%, which was 67, 64 nm.Conclusion: RPO can be formulated as a nanoemulsion by spontaneous emulsification method. RPO with a 5% concentration is very stable for 12 weeks storage.
ISSN:0974-2441
0974-2441
DOI:10.22159/ajpcr.2018.v11i9.26532