TERATOGENICITY TESTING OF SIDDHA FORMULATION OF NILAVEMBU KUDINEER ON ZEBRAFISH (DANIO RERIO) EMBRYO

Objective: The aim of the study was to evaluate the teratogenic effect of Nilavembu Kudineer (NVK) by testing in zebrafish embryo (Danio rerio). Methods: The study consisted of 30 embryos/culture plate/dose concentration containing a series of diluted decoction of NVK ranging from 10 μg to 640 μg/ml...

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Published in:Asian journal of pharmaceutical and clinical research 2019-07, p.246-250
Main Authors: SHANMUGAPRIYA P, ELANSEKARAN S, RAMAMURTHY M, JEEVA GLADYS R, SIVARAMAN D, CHRISTIAN GJ
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container_title Asian journal of pharmaceutical and clinical research
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creator SHANMUGAPRIYA P
ELANSEKARAN S
RAMAMURTHY M
JEEVA GLADYS R
SIVARAMAN D
CHRISTIAN GJ
description Objective: The aim of the study was to evaluate the teratogenic effect of Nilavembu Kudineer (NVK) by testing in zebrafish embryo (Danio rerio). Methods: The study consisted of 30 embryos/culture plate/dose concentration containing a series of diluted decoction of NVK ranging from 10 μg to 640 μg/ml, and the embryo development was monitored at specific time points. The parameters such as developmental abnormality and adverse events were monitored at 24 hourly intervals for 96 h. Results: The study results showed 100% hatching and survival of embryos with no significant abnormalities in the extension of study from 96 to 120 h post-fertilization examinations. Conclusion: NVK did not have teratogenic potential on testing it in various concentrations on zebrafish embryos validating its safety during pregnancy.
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