ANTIFUNGAL AND ANTIBIOFILM ACTIVITY OF 2-BROMO-N-PHENYLCETAMIDE AGAINST CRYPTOCOCCUS NEOFORMANS

Objective: This study aimed to evaluate the antifungal and antibiofilm of 2-bromo-N-phenylacetamide (A1Br) against Cryptococcus neoformans in vitro. Methods: The compound was characterized by infrared and 1H-nuclear magnetic resonance spectrometry data. Minimum inhibitory concentration (MIC) was det...

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Published in:Asian journal of pharmaceutical and clinical research 2020-12, p.173-176
Main Authors: DE MELO, THAMARA RODRIGUES, CORDEIRO, LAÍSA VILAR, DA SILVA SOUZA, HELIVALDO DIÓGENES, DE ATHAYDE-FILHO, PETRÔNIO FILGUEIRAS, DE OLIVEIRA-FILHO, ABRAHÃO ALVES, FERREIRA, SÁVIO BENVINDO, OLIVERIA LIMA, EDELTRUDES DE
Format: Article
Language:English
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Summary:Objective: This study aimed to evaluate the antifungal and antibiofilm of 2-bromo-N-phenylacetamide (A1Br) against Cryptococcus neoformans in vitro. Methods: The compound was characterized by infrared and 1H-nuclear magnetic resonance spectrometry data. Minimum inhibitory concentration (MIC) was determined using the plate dilution method and biofilm formation inhibition of the crystal violet assay. Results: A1Br inhibited the growth of C. neoformans with MIC of 0.25 and 0.5 μg/ml and has good antibiofilm activity MIC ×4, with ≥80% inhibition growth. Conclusions: Thus, A1Br shows potential antifungal and antibiofilm agents for the treatment of infections caused by C. neoformans, as well as the eradication of cryptococcal colonization of medical prosthetic devices.
ISSN:0974-2441
0974-2441
DOI:10.22159/ajpcr.2020.v13i12.39834