BIOLOGICAL STUDIES OF 4-AMINO BENZAMIDE DERIVED 1,2,3-TRIAZOLE LINKED CHALCONE AND ITS PYRAZOLINE DERIVATIVES

Objectives: The present work planned to investigate the anti-bacterial, anti-fungal, and anti-oxidant activity against 4-amino benzamide derived 1,2,3-triazole linked chalcone and pyrazoline derivatives. Methods: Anti-microbial activity for pyrazoline derivatives was accomplished by serial dilution...

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Bibliographic Details
Published in:Asian journal of pharmaceutical and clinical research 2022-09, p.94-97
Main Authors: S, SATHIYA, BS, KRISHNAMOORTHY, S, MEENACHI, R, RAVIKUMAR
Format: Article
Language:English
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Summary:Objectives: The present work planned to investigate the anti-bacterial, anti-fungal, and anti-oxidant activity against 4-amino benzamide derived 1,2,3-triazole linked chalcone and pyrazoline derivatives. Methods: Anti-microbial activity for pyrazoline derivatives was accomplished by serial dilution method. The test organisms of bacterial strains were (Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas fluorescence) and the fungal cultures (Aspergillus niger, Aspergillus terreus, and Trichoderma harzanium). The method used in the anti-oxidant activity is 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide scavenging method. Results: All the compounds showed good to moderate anti-bacterial and anti-fungal activities. The results of IC50 values showed lower potent inhibition activity with DPPH and higher potent inhibition activity in nitric oxide scavenging method. Conclusion: All the compounds had exhibited capricious growth inhibitory effect on anti-bacterial, anti-fungal, and anti-oxidant activities.
ISSN:0974-2441
0974-2441
DOI:10.22159/ajpcr.2022.v15i9.45089