In vitro activities of antibiotic combinations against mature biofilms of ventilator-associated pneumonia isolates

The authors aimed to determine the efficacy of frequently used antibiotics, alone or in combination, against biofilms of ventilator-associated pneumonia isolates. The authors determined the MICs, minimum biofilm inhibitory concentrations and minimum biofilm eradication concentrations of meropenem, c...

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Bibliographic Details
Published in:Future microbiology 2022-09, Vol.17 (13), p.1027-1042
Main Authors: Copur, Betul, Dosler, Sibel, Aktas, Zerrin, Basaran, Seniha, Simsek-Yavuz, Serap, Cagatay, Atahan, Oncul, Oral, Ozsut, Halit, Eraksoy, Haluk
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Anti-Bacterial Agents - pharmacology
Biofilms
Ciprofloxacin - pharmacology
Colistin - pharmacology
Drug Synergism
Humans
Meropenem - pharmacology
Microbial Sensitivity Tests
Pneumonia, Ventilator-Associated - drug therapy
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Summary:The authors aimed to determine the efficacy of frequently used antibiotics, alone or in combination, against biofilms of ventilator-associated pneumonia isolates. The authors determined the MICs, minimum biofilm inhibitory concentrations and minimum biofilm eradication concentrations of meropenem, ciprofloxacin and colistin as well as their combinations against planktonic forms and biofilms of , and clinical isolates. Generally, the minimum biofilm inhibitory concentrations and minimum biofilm eradication concentrations of the antibiotics were 1000-fold higher than their MICs, and synergy was provided by different concentrations of meropenem-colistin and meropenem-ciprofloxacin combinations with checkerboard and time-kill curve methods. The combination of meropenem and ciprofloxacin seems to be a good candidate for the treatment of biofilm-associated infections; none of the concentrations obtained as a result of the synergy test were clinically significant.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2021-0305