Sentinel lymph node detection in thyroid carcinoma using 68 Ga-tilmanocept PET/CT: a proof-of-concept study protocol

Sentinel lymph node biopsy (SLNB) is a diagnostic staging procedure. The procedure aims to identify the first draining lymph node(s), which are most likely to contain metastases. SLNB is applied in various cancers, but not currently in thyroid carcinoma. However, treatment strategies are changing, m...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2022-10, Vol.18 (31), p.3493-3499
Main Authors: de Vries, Lisa H, Lodewijk, Lutske, de Keizer, Bart, Borel Rinkes, Inne Hm, Vriens, Menno R
Format: Article
Language:English
Subjects:
Gallium Radioisotopes
Humans
Lymph Nodes - pathology
Lymphatic Metastasis - pathology
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
Sentinel Lymph Node - pathology
Sentinel Lymph Node Biopsy - methods
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - surgery
Tomography, X-Ray Computed - methods
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Summary:Sentinel lymph node biopsy (SLNB) is a diagnostic staging procedure. The procedure aims to identify the first draining lymph node(s), which are most likely to contain metastases. SLNB is applied in various cancers, but not currently in thyroid carcinoma. However, treatment strategies are changing, making SLNB clinically relevant. SLNB may lead to more accurate staging, prevent unnecessary treatment and help achieve earlier curation. Ga-tilmanocept PET/computed tomography (CT) can better localize sentinel lymph nodes (SLNs) near the primary tumor than planar scintigraphy and single-photon emission computed tomography (SPECT)/CT. This paper describes the rationale and design of a study investigating SLNB using Ga-tilmanocept PET/CT and indocyanine-green- Tc-nanocolloid in ten differentiated and medullary thyroid carcinoma patients. Localization and number of SLNs, pathology result, optimal scan protocol, surgical time and surgeon's experience are examined. 2021-002470-42 (EudraCT).
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2022-0165