Dendritic cell-based vaccine targeting aspartate-β-hydroxylas represents a promising therapeutic strategy for HCC

Dendritic cells (DCs)-mediated immunotherapy has been considered as a promising antitumor method. Aspartate-β-hydroxylase ( ) is a potential immunotherapeutic target for hepatocellular carcinoma (HCC). C57BL/6 mice were immunized by AAH-DCs vaccine constructed . Killing tumor cells effect of active...

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Bibliographic Details
Published in:Immunotherapy 2019-11, Vol.11 (16), p.1399-1407
Main Authors: Zhou, Yujiao, Li, Chengmin, Shi, Guo, Xu, Xiaolei, Luo, Xue, Zhang, Yuanling, Fu, Jingjie, Chen, Limin, Zeng, Aizhong
Format: Article
Language:English
Subjects:
adoptive T-cell therapy
apoptosis
aspartate-β-hydroxylase
dendritic cells
hepatocellular carcinoma
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Summary:Dendritic cells (DCs)-mediated immunotherapy has been considered as a promising antitumor method. Aspartate-β-hydroxylase ( ) is a potential immunotherapeutic target for hepatocellular carcinoma (HCC). C57BL/6 mice were immunized by AAH-DCs vaccine constructed . Killing tumor cells effect of active T cells induced by AAH-DCs vaccine on HCC cells were measured and . The underlying mechanism was preliminarily investigated. T cells response when activated by AAH-DCs vaccine showed a significant inhibition effect on HCC cells and in tumor-bearing mice models when compared with controls. Additionally, compared with the control group, increased expressions of Caspase8, Caspase 3 and Bax, and declined expression of Bcl-2 were observed in AAH-DCs vaccine group. AAH-DCs vaccine could stimulate T cell responses against HCC, which was possibly achieved via pro-apoptosis mechanism.
ISSN:1750-743X
1750-7448
DOI:10.2217/imt-2019-0081