Emerging advances in nanomedicine for breast cancer immunotherapy: opportunities and challenges

• Published in: Immunotherapy 2022-08, Vol.14 (12), p.957-983
• Main Authors: Ahmad, Mohammad Zaki, Alasiri, Ali S, Alasmary, Mohammed Yahia, Abdullah, MM, Ahmad, Javed, Abdel Wahab, Basel A, M Alqahtani, Saif Aboud, Pathak, Kalyani, Mustafa, Gulam, Khan, Mohammad Ahmad, Saikia, Riya, Gogoi, Urvashee
• Format: Article
• Language: English
• Subjects: breast cancer; cancer immunotherapy; cancer nanovaccines; nanomedicine; nanoparticles; vaccines
• ISSN: 1750-743X; 1750-7448
• DOI: 10.2217/imt-2021-0348

Breast cancer is one of the most common causes of cancer-related morbidity and mortality in women worldwide. Early diagnosis and an appropriate therapeutic approach for all cancers are climacterics for a favorable prognosis. Targeting the immune system in breast cancer is already a clinical reality with notable successes, specifically with checkpoint blockade antibodies and chimeric antigen receptor T-cell therapy. However, there have been inevitable setbacks in the clinical application of cancer immunotherapy, including inadequate immune responses due to insufficient delivery of immunostimulants to immune cells and uncontrolled immune system modulation. Rapid advancements and new evidence have suggested that nanomedicine-based immunotherapy may be a viable option for treating breast cancer. Cancer that begins in the breast is referred to as breast cancer. It may originate in either one or both breasts. It is one of the main causes of cancer-related death among women worldwide. Cancer immunotherapy is a game-changing treatment that improves the ability of the host defense system to spot and eliminate cancer cells with pinpoint accuracy. Cancer immunotherapy, also referred to as immuno-oncology, is a type of treatment option for breast cancer that uses the body’s natural defense system to prevent, regulate and eliminate breast cancer. Immunotherapy is used to enhance or alter the functioning of the immune system so that it can locate and destroy cancer cells. Knowing how immunotherapy works and what to anticipate can often offer peace of mind to the patient who can then make informed decisions about care, especially if immunotherapy is part of the treatment plan for a particular patient. Breast cancer is the most common cancer in women. Rapid advancements and new evidence have suggested that #nanomedicine-based immunotherapy may be a viable option for treating #breastcancer