Boron nitride nanotube@NiFe 2 O 4 : a highly efficient system for magnetohyperthermia therapy

The field of nanotechnology promotes the development of innovative and more effective cancer therapies. This work is aimed to develop a hybrid system that combines the capacity of boron nitride nanotubes (BNNTs) to be internalized by tumor cells and the ability of nickel ferrite nanoparticles to eff...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2019-12, Vol.14 (23), p.3075-3088
Main Authors: Cabral, Thaylice Cs, Ardisson, José D, de Miranda, Marcelo C, Gomes, Dawidson A, Fernandez-Outon, Luis E, Sousa, Edésia Mb, Ferreira, Tiago H
Format: Article
Language:English
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Summary:The field of nanotechnology promotes the development of innovative and more effective cancer therapies. This work is aimed to develop a hybrid system that combines the capacity of boron nitride nanotubes (BNNTs) to be internalized by tumor cells and the ability of nickel ferrite nanoparticles to efficiently release heat by induced AC magnetic heating. The systems studied were characterized by using x-ray diffractometry, transmission electron microscopy, vibrating sample magnetometry and Mössbauer spectroscopy. The ferrite nanoparticles attached to BNNT were able to achieve the required temperatures for magnetohyperthermia therapies. After cellular internalization, AC induced magnetic heating of BNNT@NiFe O can kill almost 80% of Hela cells lineage in a single cycle. This system can be a highly efficient magnetohyperthermia agent in cancer therapy.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2019-0123