Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe 2 O 4 nanoparticles

We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-coated and bovine serum albumin-coated MNPs. We employed the ACB system, gel elec...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2021-10, Vol.16 (24), p.2189-2206
Main Authors: Prospero, Andre Gonçalves, Buranello, Lais Pereira, Fernandes, Carlos Ah, Dos Santos, Lucilene Delazari, Soares, Guilherme, C Rossini, Bruno, Zufelato, Nícholas, Bakuzis, Andris Figueiroa, de Mattos Fontes, Marcos R, de Arruda Miranda, José R
Format: Article
Language:English
Subjects:
Biocompatible Materials
Magnetics
Magnetite Nanoparticles
Protein Corona
Serum Albumin, Bovine
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Summary:We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-coated and bovine serum albumin-coated MNPs. We employed the ACB system, gel electrophoresis and mass spectrometry analysis. Higher CP formation led to a greater reduction in the ACB signal intensity and circulation time. We found fewer proteins forming the CP for the bovine serum albumin-coated MNPs, which presented the highest circulation time among the MNPs studied. These data showed better biocompatibility, stability and magnetic signal uniformity in biological media for bovine serum albumin-coated MNPs than for citrate-coated MNPs and bare MNPs.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2021-0195