Diversity of pharmacogenomic variants affecting warfarin metabolism in Sri Lankans

To describe the diversity of pharmacogenomic variants affecting warfarin metabolism in Sri Lankans. Genotype data were filtered out from an anonymized database of 400 Sri Lankans, and minor allele frequencies (MAF) were calculated. Variants of , and genes were studied. Overall, and alleles had MAFs...

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Bibliographic Details
Published in:Pharmacogenomics 2022-11, Vol.23 (16), p.917-923
Main Authors: Ranasinghe, Priyanga, Sirisena, Nirmala, Senadeera, Vidarsha, Anandagoda, Gayani, Dissanayake, Vajira Hw
Format: Article
Language:English
Subjects:
Anticoagulants
Cytochrome P-450 CYP2C9 - genetics
Cytochrome P450 Family 4 - genetics
Dose-Response Relationship, Drug
Genotype
Humans
Pharmacogenomic Variants
pharmacogenomics
Sri Lanka
Vitamin K Epoxide Reductases - genetics
Warfarin
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Summary:To describe the diversity of pharmacogenomic variants affecting warfarin metabolism in Sri Lankans. Genotype data were filtered out from an anonymized database of 400 Sri Lankans, and minor allele frequencies (MAF) were calculated. Variants of , and genes were studied. Overall, and alleles had MAFs of 2.25% (95% CI: 0.80–3.70) and 10.38% (95% CI: 7.50–13.50), respectively. and alleles had MAFs of 0.13% (95% CI: 0–0.74) and 2.50% (95% CI: 0.97–4.03), respectively. MAFs of variants rs7294, rs9934438, rs8050894 and rs2884737 were 47.25% (95% CI: 42.36–52.14), 10.13% (95% CI: 7.28–13.22), 9.88% (95% CI: 7.06–12.94) and 4.88% (95% CI: 2.86–7.14), respectively. MAF of variant rs2108622 was 45.63% (95% CI: 40.87–50.63). Compared with other populations, the frequencies of some studied variants were significantly different in Sri Lankans, and these are likely to account for variability in warfarin dosage requirements.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2022-0026