Modulation of signal transduction gene expression following pulsed radiofrequency in dorsal root ganglia and pregabalin therapy

A randomized controlled study was conducted to assess modulation of signal transduction genes ( , and ) following integrated multimodal approach encompassing pulsed radiofrequency treatment (PRF) of dorsal root ganglion and pregabalin in thoracic postherpetic neuralgia (PHN). Clinical variables such...

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Bibliographic Details
Published in:Pain management (London) 2022-04, Vol.12 (3), p.347-356
Main Authors: Saxena, Ashok Kumar, Singh, Anshul, Chilkoti, Geetanjali T, Sharma, Tusha, Banerjee, Basu Dev, Das, Swati, Singhal, Archana
Format: Article
Language:English
Subjects:
chronic pain
pain management
postherpetic neuralgia
pregabalin
pulsed radiofrequency
quality of life
signal transduction genes
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Summary:A randomized controlled study was conducted to assess modulation of signal transduction genes ( , and ) following integrated multimodal approach encompassing pulsed radiofrequency treatment (PRF) of dorsal root ganglion and pregabalin in thoracic postherpetic neuralgia (PHN). Clinical variables such as pain intensity and quality of life were also explored.  A total of 40 Patients of PHN were recruited. 20 patients randomly assigned to each of the two groups, group PP administered PRF with pregabalin and group SP administered pregabalin alone. Significant downregulation of and observed in group PP at end of 10th week (p 
ISSN:1758-1869
1758-1877
DOI:10.2217/pmt-2021-0057