Modulation of signal transduction gene expression following pulsed radiofrequency in dorsal root ganglia and pregabalin therapy

A randomized controlled study was conducted to assess modulation of signal transduction genes ( , and ) following integrated multimodal approach encompassing pulsed radiofrequency treatment (PRF) of dorsal root ganglion and pregabalin in thoracic postherpetic neuralgia (PHN). Clinical variables such...

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Published in:Pain management (London) 2022-04, Vol.12 (3), p.347-356
Main Authors: Saxena, Ashok Kumar, Singh, Anshul, Chilkoti, Geetanjali T, Sharma, Tusha, Banerjee, Basu Dev, Das, Swati, Singhal, Archana
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Language:English
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chronic pain
pain management
postherpetic neuralgia
pregabalin
pulsed radiofrequency
quality of life
signal transduction genes
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container_issue 3
container_start_page 347
container_title Pain management (London)
container_volume 12
creator Saxena, Ashok Kumar
Singh, Anshul
Chilkoti, Geetanjali T
Sharma, Tusha
Banerjee, Basu Dev
Das, Swati
Singhal, Archana
description A randomized controlled study was conducted to assess modulation of signal transduction genes ( , and ) following integrated multimodal approach encompassing pulsed radiofrequency treatment (PRF) of dorsal root ganglion and pregabalin in thoracic postherpetic neuralgia (PHN). Clinical variables such as pain intensity and quality of life were also explored.  A total of 40 Patients of PHN were recruited. 20 patients randomly assigned to each of the two groups, group PP administered PRF with pregabalin and group SP administered pregabalin alone. Significant downregulation of and observed in group PP at end of 10th week (p 
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People who had nerve pain after recovering from a herpes attack (postherpetic neuralgia) were treated with pulsed radiofrequency (PRF) treatment of the dorsal root ganglion, which involves stimulating a nerve cluster at the base of the spine with radio waves, along with oral pregabalin therapy, or with pregabalin alone. Certain pain genes such PKA, PKC and ERK were found to be suppressed after the combined treatment with PRF and pregabalin. The suppression of these genes was also associated with the self-reported pain scores of the participants in the study. 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subjects chronic pain
pain management
postherpetic neuralgia
pregabalin
pulsed radiofrequency
quality of life
signal transduction genes
title Modulation of signal transduction gene expression following pulsed radiofrequency in dorsal root ganglia and pregabalin therapy
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