Modulation of nickel-induced bursting with 4-aminopyridine in leech retzius nerve cells

Paroxysmal depolarization shift has been identified as a characteristic feature of the cellular basis of epilepsy. On Na+-dependent bursting, 1 mmol/l 4-aminopyridine (4-AP) produced a two-phase effect - a significant depolarization accompanied by an increase in the frequency of bursting, followed b...

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Published in:Archives of biological sciences 2010, Vol.62 (4), p.1035-1045
Main Authors: Pathak, Dhruba, Lopicic, S., Bratic-Stanojevic, Marija, Pavlovic, D., Andjus, P.R., Nedeljkov, V.
Format: Article
Language:English
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Summary:Paroxysmal depolarization shift has been identified as a characteristic feature of the cellular basis of epilepsy. On Na+-dependent bursting, 1 mmol/l 4-aminopyridine (4-AP) produced a two-phase effect - a significant depolarization accompanied by an increase in the frequency of bursting, followed by repolarization along with a diminished frequency of bursting. Neither 1 ?mol/l apamin nor 150 nmol/l charybdotoxin (ChTX) elicited any significant effect on either bursting or standard conditions. Our results suggest that 4-AP affects the bursting indirectly by altering the excitability of the cell. The lack of effects of apamin and ChTX is probably due to channel insensitivity to these blockers in leech. nema PR Projekat Ministarstva nauke Republike Srbije, br. 143054
ISSN:0354-4664
1821-4339
DOI:10.2298/ABS1004035P