Toxicity of endotoxin to chicks [Escherichia coli]

Large doses of purified lipopolysaccharide (LPS) purified from Escherichia coli induced clinical signs but no mortality in chicks. Five chicks survived a mean dose of 517 mg/kg. One individual that received LPS at 577 mg/kg recovered from clinical manifestations within two days. Attempts failed to p...

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Bibliographic Details
Published in:Avian diseases 1979-01, Vol.23 (1), p.174-178
Main Authors: Adler, H.E, DaMassa, A.J
Format: Article
Language:English
Subjects:
Animals
Bacterial Toxins - toxicity
Birds
Chickens
Chickens - physiology
Depressive disorders
Dosage
Dose-Response Relationship, Drug
Endotoxins
Endotoxins - toxicity
Inoculation
Mammals
Mortality
Toxicity
Uric acid
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Summary:Large doses of purified lipopolysaccharide (LPS) purified from Escherichia coli induced clinical signs but no mortality in chicks. Five chicks survived a mean dose of 517 mg/kg. One individual that received LPS at 577 mg/kg recovered from clinical manifestations within two days. Attempts failed to produce a generalized Shwartzman-like reaction with two intravenous inoculations of LPS at about 24-hour intervals. Prior injection of uric acid did not protect chicks from LPS by intravenous exposure.
ISSN:0005-2086
1938-4351
DOI:10.2307/1589684