Characterization of Dose-Response Relationships Inferred by Statistically Significant Trend Tests

A method is proposed for classifying various experimental outcomes associated with statistically significant trend tests according to a set of results of sequential testing within a family of closed (under intersections) one-sided tests. The intent of the procedure is to characterize the general sha...

Full description

Saved in:
Bibliographic Details
Published in:Biometrics 1991-03, Vol.47 (1), p.139-146
Main Authors: Kodell, Ralph L., Chen, James J.
Format: Article
Language:English
Subjects:
Animals
Applied statistics
Bioassay
Biological and medical sciences
Biometrics
Biometry
Carcinogens - administration & dosage
Carcinogens - toxicity
Data Interpretation, Statistical
Dosage
Dose response relationship
Dose-Response Relationship, Drug
Error rates
Experimental procedures
Fundamental and applied biological sciences. Psychology
General aspects
Neoplasms, Experimental - chemically induced
Null hypothesis
Statistical significance
Tumors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A method is proposed for classifying various experimental outcomes associated with statistically significant trend tests according to a set of results of sequential testing within a family of closed (under intersections) one-sided tests. The intent of the procedure is to characterize the general shape of implied dose-response relationships, taking care neither to inflate the false-positive (Type I) error rate by overtesting, nor to sacrifice power by overadjusting for mulitple comparisons.
ISSN:0006-341X
1541-0420
DOI:10.2307/2532502