Testing Familial Aggregation

Likelihood calculation for pedigrees is complicated and often time-consuming. Testing correlation structures due to familial aggregation is therefore a preliminary procedure. A score statistic is given to check correlations between relatives of randomly chosen pedigrees. This statistic can be used f...

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Bibliographic Details
Published in:Biometrics 1995-12, Vol.51 (4), p.1292-1301
Main Authors: Houwing-Duistermaat, Jeanine J., Bert H. F. Derkx, Rosendaal, Frits R., van Houwelingen, Hans C.
Format: Article
Language:English
Subjects:
Aggregation
Alleles
Approximation
Biometry - methods
Blood - drug effects
Correlations
Endotoxins - toxicity
Female
Gene Frequency
Genes, Dominant
Genotypes
Humans
In Vitro Techniques
Likelihood Functions
Male
Medical genetics
Modeling
Models, Genetic
Monocytes - drug effects
Null hypothesis
Pedigree
Simulations
Statistical variance
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Description
Summary:Likelihood calculation for pedigrees is complicated and often time-consuming. Testing correlation structures due to familial aggregation is therefore a preliminary procedure. A score statistic is given to check correlations between relatives of randomly chosen pedigrees. This statistic can be used for quantitative and dichotomous data. For both data types, the distribution of the statistic under the null hypothesis is derived. To demonstrate the performance of the statistic, results of simulations under various models are given. Finally, the test is applied to data on a continuous blood factor.
ISSN:0006-341X
1541-0420
DOI:10.2307/2533260