Case study in data analysis: The genetic analysis of inflammatory bowel disease

Four teams of analysts try to determine the existence of an association between inflammatory bowel disease and certain genetic markers on human chromosome number 6. Their investigation involves data on several control populations and on 110 familles with two or more affected individuals. The problem...

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Bibliographic Details
Published in:Canadian journal of statistics 2002-03, Vol.30 (1), p.137-145
Format: Article
Language:English
Subjects:
Association
association analysis
candidate gene
Crohn disease
genetic association
genetic linkage
heterogeneity
human leukocyte antigen
identical by descent
inflammatory bowel disease
linkage analysis
linkage analysis with covariates
LOD score
logistic regression
Markov chain Monte Carlo
multiallelic marker
multiple comparisons
multipoint test
nonparametric likelihood
regression trees
statistical genetics
transmission/disequilibrium test
ulcerative colitis
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Summary:Four teams of analysts try to determine the existence of an association between inflammatory bowel disease and certain genetic markers on human chromosome number 6. Their investigation involves data on several control populations and on 110 familles with two or more affected individuals. The problem is introduced by Mirea, Bull, Silverberg and Siminovitch; they and three other groups (Chen, Kalbfleisch and Romero‐Hidalgo; Darlington and Paterson; Roslin, Loredo‐Osti, Greenwood and Morgan) present analyses. Their approaches are discussed by Field and Smith. Éude de cas en analyse des données: L'analyse génétique des maladies intestinales inflammatoires Quatre équipes d'analystes cherchent à déterminer s'il existe chez l'humain une association entre les maladies intestinales inflammatoires et certains marqueurs génétiques situés sur le 6ième chromosome. Ils disposent pour ce faire de données sur diverses populations type et sur 110 familles dont au moins deux des membres sont affectés par la maladie. La problématique est d'abord décrite par Mirea, Bull, Silverberg et Siminovitch; suivent leur analyse et celle des trois autres groupes (Chen, Kalbfleisch et Romero‐Hidalgo; Darlington et Paterson; Roslin, Loredo‐Osti, Greenwood et Morgan). Leurs approches sont commentées par Field et Smith.
ISSN:0319-5724
1708-945X
DOI:10.2307/3315870