Commentary: Trends in Quantitative Cancer Risk Assessment

Quantitative cancer risk assessment is a dynamic field, more closely coupled to rapidly advancing biomedical research than ever before. Six areas of change and growth are identified: expansion from models of cancer initiation to a more complete picture of the total carcinogenic process; trend from c...

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Bibliographic Details
Published in:Environmental health perspectives 1991-01, Vol.90, p.297-298
Main Author: Morris, Samuel C.
Format: Article
Language:English
Subjects:
Biomedical research
Cancer
Carcinogenesis
Developmental biology
Drug design
Expert systems
Mathematical extrapolation
Modeling
Modeling Methodologies for Carcinogenic Risk Assessment
Pharmacokinetics
Risk analysis
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Summary:Quantitative cancer risk assessment is a dynamic field, more closely coupled to rapidly advancing biomedical research than ever before. Six areas of change and growth are identified: expansion from models of cancer initiation to a more complete picture of the total carcinogenic process; trend from curve-fitting to biologically based models; movement from upper-bound estimates to best estimates, with a more complete treatment of uncertainty; increased consideration of the role of susceptibility; growing development of expert systems and decision support systems; and emerging importance of risk communication.
ISSN:0091-6765
DOI:10.2307/3430882