The Effects of Radiation and Ethionine on Rat Mammary Tumor Incidence

A single, sublethal dose of x-radiation (175 rads) to the whole body or liver of Osborn-Mendel female rats fed dl-ethionine for 5 1/2 months has resulted in an increased incidence of rats with mammary tumors in the whole-body-irradiated but not in the liver-irradiated or control rats. This increase...

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Bibliographic Details
Published in:Radiation research 1969-03, Vol.37 (3), p.577-589
Main Authors: Telles, Norman C., Ward, Billy C.
Format: Article
Language:English
Subjects:
Animals
Body Weight
Carcinogens
Death
Diet
Ethionine - toxicity
Liver
Liver - anatomy & histology
Liver - drug effects
Liver - radiation effects
Mammary glands
Mammary Neoplasms, Experimental - chemically induced
Mammary Neoplasms, Experimental - etiology
Neoplasia
Neoplasms, Radiation-Induced
Organ Size
Radiation Effects
Radiotherapy
Rats
Tumors
Whole body irradiation
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Summary:A single, sublethal dose of x-radiation (175 rads) to the whole body or liver of Osborn-Mendel female rats fed dl-ethionine for 5 1/2 months has resulted in an increased incidence of rats with mammary tumors in the whole-body-irradiated but not in the liver-irradiated or control rats. This increase appears to be related to the dietary level of ethionine. It was not apparent until at least 6 months after ethionine was removed from the diet. Incidence of mammary tumors for control and liver-irradiated rats was unchanged or slightly reduced with ethionine.
ISSN:0033-7587
1938-5404
DOI:10.2307/3572696