Heme and globin synthesis and related parameters in blood from the X-irradiated duck

Decreases in the rates of heme and globin synthesis, turnover of free protoporphyrin, transfer of plasma iron to erythrocytes, and incorporation of plasma iron into heme in duck blood in vitro and in the concentration of protoporphyrin and proportion of reticulocytes in blood were observed at 1 to 8...

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Bibliographic Details
Published in:Radiation research 1969, Vol.37 (1), p.50-56
Main Author: Klein, J.R
Format: Article
Language:English
Subjects:
animal science
Animals
Blood
Blood - radiation effects
Blood plasma
Blood Proteins - biosynthesis
Bone marrow
Carbon Isotopes
Ducks
Erythrocytes
Erythrocytes - metabolism
Erythropoiesis - radiation effects
Globins - biosynthesis
Glycine - metabolism
Heme - biosynthesis
Hemoglobins
Hemoglobins - biosynthesis
Iron - metabolism
Iron Isotopes
Irradiation
Porphyrins
Porphyrins - metabolism
Protoporphyrins
Radiation Effects
Reticulocytes
Time Factors
zoology
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Summary:Decreases in the rates of heme and globin synthesis, turnover of free protoporphyrin, transfer of plasma iron to erythrocytes, and incorporation of plasma iron into heme in duck blood in vitro and in the concentration of protoporphyrin and proportion of reticulocytes in blood were observed at 1 to 8 days after x-irradiation of the animal. The decreases in rates and porphyrin concentration apparently were a consequence of the decrease in reticulocytes-that is, of erythropoietic arrest. The various parameters were found unchanged at 5 and 30 minutes after irradiation of the animal and after direct irradiation of blood. The estimations of synthesis and porphyrin turnover were based on incorporation of$\text{glycine-}2\text{-}{}^{14}{\rm C}$, the other rates on incorporation of labeled iron.
ISSN:0033-7587
1938-5404
DOI:10.2307/3572750