Radioprotective Effect of Sodium Fluoroacetate in Mice

A quantitative study of the radioprotective effect of sodium fluoroacetate (FAc) in white mice of H-strain, 9-12 weeks old was made. The results of the experiments show that FAc administered intraperitoneally 3 hours before irradiation in the amount of 7.5 mg/kg increases the average ${\rm LD}_{50(3...

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Published in:Radiation research 1969-11, Vol.40 (2), p.430-439
Main Authors: Novák, L., Šikulová, J., Hošek, B., Mišustová, J.
Format: Article
Language:English
Subjects:
Animals
Body temperature
Dosage
Fluoroacetates - pharmacology
Hypoxia
Injections, Intraperitoneal
Intraperitoneal injections
Irradiation
Laboratory animals
Metabolism
Mice
Protective effects
Radiation Injuries, Experimental - mortality
Radiation-Protective Agents - pharmacology
Sodium
Sodium - pharmacology
Time Factors
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container_issue 2
container_start_page 430
container_title Radiation research
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creator Novák, L.
Šikulová, J.
Hošek, B.
Mišustová, J.
description A quantitative study of the radioprotective effect of sodium fluoroacetate (FAc) in white mice of H-strain, 9-12 weeks old was made. The results of the experiments show that FAc administered intraperitoneally 3 hours before irradiation in the amount of 7.5 mg/kg increases the average ${\rm LD}_{50(30)}$ value from 648 R (controls) to 998 R (protected). A comparison of the obtained results with data on the radioprotective effect of cysteine, cysteamine, AET, serotonin and hypoxia indicates that the radioprotective effect of FAc is not statistically different from the effect of these compounds. The protective effect of FAc, however, requires much smaller doses (50-75 μmoles/kg). At the same time the duration of protection after FAc administration is much longer, lasting roughly from 30 minutes to 7 hours after the application of the substance, with maximum protection between the first and second hour.
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The results of the experiments show that FAc administered intraperitoneally 3 hours before irradiation in the amount of 7.5 mg/kg increases the average ${\rm LD}_{50(30)}$ value from 648 R (controls) to 998 R (protected). A comparison of the obtained results with data on the radioprotective effect of cysteine, cysteamine, AET, serotonin and hypoxia indicates that the radioprotective effect of FAc is not statistically different from the effect of these compounds. The protective effect of FAc, however, requires much smaller doses (50-75 μmoles/kg). 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1938-5404
language eng
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source JSTOR Archival Journals and Primary Sources Collection
subjects Animals
Body temperature
Dosage
Fluoroacetates - pharmacology
Hypoxia
Injections, Intraperitoneal
Intraperitoneal injections
Irradiation
Laboratory animals
Metabolism
Mice
Protective effects
Radiation Injuries, Experimental - mortality
Radiation-Protective Agents - pharmacology
Sodium
Sodium - pharmacology
Time Factors
title Radioprotective Effect of Sodium Fluoroacetate in Mice
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