Immunological Reactions after Irradiation of the Uterus

Antibodies to the mucosa of the portio and uterus were studied in 80 patients before and after intensive local irradiation by intracavitary application of radium. In addition, an examination was made of 30 apparently healthy women of the same age groups, who had not been submitted to irradiation. An...

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Bibliographic Details
Published in:Radiation research 1969-11, Vol.40 (2), p.465-472
Main Authors: Einhorn, Nina, Jonsson, Jonas, Fagraeus, Astrid
Format: Article
Language:English
Subjects:
Antibodies
Antibody Formation - radiation effects
Biological Assay
Cell nucleus
Cervix uteri
Epithelial cells
Epithelium
Female
Fluorescent Antibody Technique
Globulins
HeLa Cells
Humans
Irradiation
Radiation Effects
Radium
Radium - therapeutic use
Uterine Cervical Neoplasms - radiotherapy
Uterine Neoplasms - radiotherapy
Uterus
Uterus - immunology
Uterus - radiation effects
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Summary:Antibodies to the mucosa of the portio and uterus were studied in 80 patients before and after intensive local irradiation by intracavitary application of radium. In addition, an examination was made of 30 apparently healthy women of the same age groups, who had not been submitted to irradiation. Antibodies to a cell line derived from a malignant uterine tumour were also examined in the sera from the patients, as were antibodies to thyroid cytoplasmic antigen, thyroglobulin, bovine gamma globulin, parietal cells and cell nuclei. Antibodies to the uterine tissues were observed before irradiation in some patients and also in some of the healthy controls. After intensive local irradiation there was a significant increase in antibodies to the epithelial cells of the portio and to the cervical gland cells. This increase would seem to be limited to antibodies to the irradiated tissue, since no increase in antibodies to any of various other tissues studied was observed.
ISSN:0033-7587
1938-5404
DOI:10.2307/3572833