Long-Term Hematological Effects of Internal Emitters in Beagles

The hematological effects of five internal emitters injected into adult beagles have been analyzed for 8 years postinjection. Five to seven dose levels were utilized per radionuclide ranging from near permissible levels to levels causing bone tumors. The main hematological alterations were depressio...

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Bibliographic Details
Published in:Radiation research 1971-11, Vol.48 (2), p.319-331
Main Authors: Dougherty, Jean H., Rosenblatt, Leon S.
Format: Article
Language:English
Subjects:
Animals
Blood Cell Count
Dogs
Eosinophils
Female
Hematocrit
Hematopoietic System - radiation effects
Injections, Intravenous
Irradiation
Leukocytes
Lymphocytes
Lymphopenia
Male
Monocytes
Neutrophils
Nuclides
Plutonium
Radiation Dosage
Radiation Effects
Radionuclides
Radium
Species Specificity
Statistics as Topic
Strontium Isotopes
Thorium
Time Factors
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Description
Summary:The hematological effects of five internal emitters injected into adult beagles have been analyzed for 8 years postinjection. Five to seven dose levels were utilized per radionuclide ranging from near permissible levels to levels causing bone tumors. The main hematological alterations were depression of granular leukocytes and, to a lesser extent, erythrocytes. The depressions of leukocytes were dose dependent. Some recovery was noted at higher levels for polymorphonuclear leukocytes but not for lymphocytes. Transient depressions of blood cells were seen at lower dose levels. For any type of cell, minimal values were similar for all radionuclides and at comparable dose levels. Relative toxicities of the radionuclides to the hematopoietic system were related to deposition patterns and type of particle emission.
ISSN:0033-7587
1938-5404
DOI:10.2307/3573316