Reduced Production of Spleen Colonies and Granulocytes in Antibiotic-Treated Irradiated Mice Transplanted with Syngeneic Bone Marrow

The effects of gentamicin, tetracycline, and a combination of neomycin and sulfathiazole on bone marrow proliferation were studied in mice. Spleen colony and granulocyte production by syngeneic bone marrow transplanted to lethally irradiated mice were significantly decreased when antibiotics were ad...

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Bibliographic Details
Published in:Radiation research 1971-10, Vol.48 (1), p.20-31
Main Authors: Preisler, Harvey D., Bruckner, Howard, Henderson, Edward S.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antibiotics
Bone marrow
Bone Marrow - drug effects
Bone Marrow Cells
Bone Marrow Transplantation
Endotoxins
Female
Gentamicins - pharmacology
Germ free state
Granulocytes
Leukocyte Count
Leukocytes
Leukocytes - drug effects
Mice
Mice, Inbred Strains - radiation effects
Neomycin - pharmacology
Radiation Effects
Spleen
Spleen - drug effects
Sulfathiazoles - pharmacology
Tap water
Tetracycline - pharmacology
Transplantation
Transplantation, Homologous
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Summary:The effects of gentamicin, tetracycline, and a combination of neomycin and sulfathiazole on bone marrow proliferation were studied in mice. Spleen colony and granulocyte production by syngeneic bone marrow transplanted to lethally irradiated mice were significantly decreased when antibiotics were administered to the marrow recipients. Antibiotic administration to marrow donors had no effect on marrow proliferation before or after transplantation. It is likely that the observed effects were the result of alterations in the gastrointestinal flora of the marrow transplant recipients.
ISSN:0033-7587
1938-5404
DOI:10.2307/3573391