The Morphological and Cytogenetic Effects of Laser Power at 2650 Å on Chinese Hamster Cells In Vitro

Chinese hamster cells (DON-C pseudodiploid strain) were exposed to multiple flashes of $2.3\ {\rm mJ}/{\rm cm}^{2}$ from a frequency-quadrupled neodymium laser operating at 2650 Å. This cell type showed a marked decrease in cell number within 48 hours after treatment, but subsequent growth rates wer...

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Bibliographic Details
Published in:Radiation research 1972-04, Vol.50 (1), p.85-93
Main Authors: Okigaki, T., Rounds, D. E.
Format: Article
Language:English
Subjects:
Cell growth
Cell lines
Cell nucleus
Chromosome aberrations
Chromosomes
Giant cells
Laser damage
Laser power
Lasers
Ultraviolet lasers
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Summary:Chinese hamster cells (DON-C pseudodiploid strain) were exposed to multiple flashes of $2.3\ {\rm mJ}/{\rm cm}^{2}$ from a frequency-quadrupled neodymium laser operating at 2650 Å. This cell type showed a marked decrease in cell number within 48 hours after treatment, but subsequent growth rates were found to be equivalent to that of control cell populations. Other effects of UV-laser treatment included a decrease in the mitotic index and an increase in the number of cells showing nuclear abnormalities. In addition, laser energy at 2650 Å produced all known types of chromosomes and chromatid aberrations. The effect produced by this UV-energy source appeared to be quantitatively less, but qualitatively similar to cellular effects produced by conventional UV sources.
ISSN:0033-7587
1938-5404
DOI:10.2307/3573470