Radiation Mortality in the Chinese Hamster, Cricetulus griseus, in Relation to Age

Chinese hamsters (Cricetulus griseus) were given whole-body x-radiation at 1, 3, 7, 15, 30, 71, 100, 150, and 250 days of age. Probit dose-mortality curves, ${\rm LD}_{50(30)}$ values, and mean survival times were determined for each age. The ${\rm LD}_{50(30)}$ values were lowest at 1 day of age (6...

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Bibliographic Details
Published in:Radiation research 1972-09, Vol.51 (3), p.599-607
Main Authors: Ward, B. C., Childress, J. R., Jessup, G. L., Lappenbusch, W. L.
Format: Article
Language:English
Subjects:
Age
Age Factors
Age groups
Animals
Chinese hamsters
Confidence limits
Cricetinae
Ionizing radiation
Lethal Dose 50
Life tables
Mortality
Radiation Dosage
Radiation Injuries, Experimental - mortality
Radiation protection
Radiation tolerance
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Summary:Chinese hamsters (Cricetulus griseus) were given whole-body x-radiation at 1, 3, 7, 15, 30, 71, 100, 150, and 250 days of age. Probit dose-mortality curves, ${\rm LD}_{50(30)}$ values, and mean survival times were determined for each age. The ${\rm LD}_{50(30)}$ values were lowest at 1 day of age (635 rads), increased rapidly to a peak of 983 rads at 100 days of age, and then decreased slightly to 910 rads at 150 and 250 days of age. The age sensitivity of the Chinese hamster was found to be similar to that of the rat but different from the age-sensitivity response of the mouse or dog.
ISSN:0033-7587
1938-5404
DOI:10.2307/3573628