Systemic protection against radiation. II. Effect of protein and lipid constituents of diet

Ratios of nonhydrolyzed versus hydrolyzed nitrogenous constituents (NHP:HP) and medium-chain versus long-chain triglycerides (MCT:LCT) were modified in five formula-defined diets fed to male rats. We measured the effects of these dietary modifications on the incorporation of ^{3}{\rm H}-{\rm TdR}$ i...

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Bibliographic Details
Published in:Radiation research 1976-05, Vol.66 (2), p.267-273
Main Authors: Pageau, R, Bounous, G
Format: Article
Language:English
Subjects:
Animals
Bone marrow
Bone Marrow - metabolism
Bone marrow cells
Cobalt Radioisotopes
Diet
Dietary Fats - therapeutic use
Dietary Proteins - therapeutic use
Gamma Rays
Irradiation
Lymph nodes
Lymph Nodes - metabolism
Male
Nuclear medicine
Nuclear radiation
Radiation Injuries, Experimental - diet therapy
Radiation Injuries, Experimental - metabolism
Radiation Injuries, Experimental - prevention & control
Radiation protection
Rats
Spleen
Spleen - metabolism
Thymidine - metabolism
Thymus Gland - metabolism
Triglycerides
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Summary:Ratios of nonhydrolyzed versus hydrolyzed nitrogenous constituents (NHP:HP) and medium-chain versus long-chain triglycerides (MCT:LCT) were modified in five formula-defined diets fed to male rats. We measured the effects of these dietary modifications on the incorporation of ^{3}{\rm H}-{\rm TdR}$ in the thymus, the spleen, the lymph nodes, and the bone marrow of nonirradiated animals as well as on the survival of animals given total-body irradiation of 700 rad. It was found that both ^{3}{\rm H}-{\rm TdR}$ incorporation in hematopoietic tissues (especially the bone marrow) and the ability to withstand the effects of 700 rad were inversely proportional to the NHP content of the diets. In the case of the lipidic constituents, a ratio of 1 MCT:4 LCT (providing that nitrogenous materials were present in a hydrolyzed form) gave the best results both in terms of a higher uptake of ^{3}{\rm H}-{\rm TdR}$ by hematopoietic tissues and a greater resistance to radiation.
ISSN:0033-7587
1938-5404
DOI:10.2307/3574395