Dominant Lethal Mutations in Mice Resulting from Chronic Tritiated Water (HTO) Ingestion

The possible genetic consequences of continued ingestion of tritiated water (HTO) have been investigated in Hale-Stoner-Brookhaven strain mice maintained on HTO (3 μCi/ml). Second-generation females on HTO were sacrificed in late pregnancy and the corpora lutea, viable, nonviable embryos (early deat...

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Bibliographic Details
Published in:Radiation research 1976-06, Vol.66 (3), p.609-614
Main Authors: Carsten, A. L., Commerford, S. L.
Format: Article
Language:English
Subjects:
Animals
Blood plasma
Breeding
Dominant lethals
Embryos
Female
Genes, Dominant
Genes, Lethal
Genetic mutation
Male
Male animals
Mice
Mutation
Pregnancy
Radiation dosage
Radiation Genetics
Tap water
Tritium
Water Pollution, Radioactive
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Summary:The possible genetic consequences of continued ingestion of tritiated water (HTO) have been investigated in Hale-Stoner-Brookhaven strain mice maintained on HTO (3 μCi/ml). Second-generation females on HTO were sacrificed in late pregnancy and the corpora lutea, viable, nonviable embryos (early death and late death) and preimplantation loss determined to calculate the mutation rate. The breeding efficiency (pregnancy rate and litter size), was also measured. Analysis of results by both parametric and nonparametric tests has indicated a significant reduction in the number of viable embryos resulting from matings between animals maintained on the tritium regimen, with no effect on breeding efficiency. The integrated radiation dose to the testes and ovary, based on average tissue tritium content from fetal origin through breeding of the 8-week-old animals, was calculated.
ISSN:0033-7587
1938-5404
DOI:10.2307/3574464