Radiation effects on membranes. I. Vitamin E deficiency and lipid peroxidation

Mice which had received a vitamin E-deficient diet from weaning on, were more sensitive to X irradiation than were normal mice, ${\rm LD}_{50/30}$ being decreased by 0.25 Gy. The vitamin E-deficient mice also showed an increased spleen shrinkage. The cellular membranes of the vitamin E-deficient mic...

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Bibliographic Details
Published in:Radiation research 1979-12, Vol.80 (3), p.494-501
Main Authors: Konings, A.W.T, Drijver, E.B
Format: Article
Language:English
Subjects:
Animals
Cell membranes
Dose-Response Relationship, Radiation
Erythrocytes
Fatty acids
Glutathione - pharmacology
In Vitro Techniques
Intracellular Membranes - drug effects
Intracellular Membranes - metabolism
Intracellular Membranes - radiation effects
Irradiation
Lipids
Liver
Liver - metabolism
Membrane Lipids - metabolism
Mice
Mice, Inbred C57BL
Peroxides - metabolism
Radiation Injuries, Experimental - complications
Radiation Injuries, Experimental - metabolism
Radiation tolerance
Radiation-Protective Agents - pharmacology
Time Factors
Vitamin E
Vitamin E Deficiency - complications
Vitamin E Deficiency - metabolism
X-Rays
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Summary:Mice which had received a vitamin E-deficient diet from weaning on, were more sensitive to X irradiation than were normal mice, ${\rm LD}_{50/30}$ being decreased by 0.25 Gy. The vitamin E-deficient mice also showed an increased spleen shrinkage. The cellular membranes of the vitamin E-deficient mice were more vulnerable to lipid peroxidation. X irradiation in vivo shortened the lag period prior to rapid lipid peroxidation as measured in vitro. Injection of the mice with glutathione prior to X irradiation protected the membranes in the in vitro test of peroxidation capacity as was demonstrated by an extended lag period. The possible meaning of these results with respect to the concept that membranes may be important sites for radiation damage is discussed.
ISSN:0033-7587
1938-5404
DOI:10.2307/3574991