Salicylic Acid Failed to Increase the Efficacy of Ca-DTPA in the Decorporation of Plutonium and Americium

Male and female C57BL/Do mice were each given a single ip injection of ^{237+239}{\rm Pu}+{}^{241}{\rm Am}$ as the citrate complex at 45 days of age. Twice-weekly ip injections of either 500 μmole/kg Ca-DTPA or 500 μmole/kg Ca-DTPA mixed just before injection with 2000 μmole/kg salicylic acid (SA) w...

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Bibliographic Details
Published in:Radiation research 1980-10, Vol.84 (1), p.149-151
Main Authors: Jones, Craig W., Lloyd, Ray D., Mays, Charles W.
Format: Article
Language:English
Subjects:
Americium
Americium - metabolism
Animals
Calcium - administration & dosage
Chelation therapy
Citrates
Correspondence
Drug Synergism
Female
Intraperitoneal injections
Ligands
Male
Mice
Mice, Inbred C57BL
Nuclides
Pentetic Acid - administration & dosage
Plutonium
Plutonium - metabolism
Radiobiology
Salicylates - pharmacology
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Summary:Male and female C57BL/Do mice were each given a single ip injection of ^{237+239}{\rm Pu}+{}^{241}{\rm Am}$ as the citrate complex at 45 days of age. Twice-weekly ip injections of either 500 μmole/kg Ca-DTPA or 500 μmole/kg Ca-DTPA mixed just before injection with 2000 μmole/kg salicylic acid (SA) were begun 3 days after nuclide administration and continued for 5 weeks. Control mice were injected each time with isotonic saline. Nuclide retention was determined by in vivo γ-ray counting using a NaI(T1) crystal spectrometer. At the end of treatment, total-body retention of Pu or Am in the mice given Ca-DTPA was significantly lower (P < 0.001) than that in the control animals. Mice treated with Ca-DTPA plus SA were statistically indistinguishable from mice treated with Ca-DTPA alone (P > 0.70 for ^{237}{\rm Pu}$ and P > 0.20 for 241 Am).
ISSN:0033-7587
1938-5404
DOI:10.2307/3575226