Salicylic Acid Failed to Increase the Efficacy of Ca-DTPA in the Decorporation of Plutonium and Americium

• Published in: Radiation research 1980-10, Vol.84 (1), p.149-151
• Main Authors: Jones, Craig W., Lloyd, Ray D., Mays, Charles W.
• Format: Article
• Language: English
• Subjects: Americium; Americium - metabolism; Animals; Calcium - administration & dosage; Chelation therapy; Citrates; Correspondence; Drug Synergism; Female; Intraperitoneal injections; Ligands; Male; Mice; Mice, Inbred C57BL; Nuclides; Pentetic Acid - administration & dosage; Plutonium; Plutonium - metabolism; Radiobiology; Salicylates - pharmacology
• ISSN: 0033-7587; 1938-5404
• DOI: 10.2307/3575226

Male and female C57BL/Do mice were each given a single ip injection of ^{237+239}{\rm Pu}+{}^{241}{\rm Am}$ as the citrate complex at 45 days of age. Twice-weekly ip injections of either 500 μmole/kg Ca-DTPA or 500 μmole/kg Ca-DTPA mixed just before injection with 2000 μmole/kg salicylic acid (SA) were begun 3 days after nuclide administration and continued for 5 weeks. Control mice were injected each time with isotonic saline. Nuclide retention was determined by in vivo γ-ray counting using a NaI(T1) crystal spectrometer. At the end of treatment, total-body retention of Pu or Am in the mice given Ca-DTPA was significantly lower (P < 0.001) than that in the control animals. Mice treated with Ca-DTPA plus SA were statistically indistinguishable from mice treated with Ca-DTPA alone (P > 0.70 for ^{237}{\rm Pu}$ and P > 0.20 for 241 Am).