The Effects of X Radiation on the Canine Heart

Ten dogs received a single exposure of 10 MeV X rays to the heart. Five dogs received 1500 rad to the midline and five received 1000 rad. When the dogs expired or were killed 73-85 days after irradiation, their hearts were examined pathologically. The changes most frequently observed were pericardia...

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Bibliographic Details
Published in:Radiation research 1980-04, Vol.82 (1), p.200-210
Main Authors: Stryker, John A., Lee, Kap J., Abt, Arthur B.
Format: Article
Language:English
Subjects:
Animals
Canines
Dogs
Endomyocardial Fibrosis - etiology
Endomyocardial Fibrosis - pathology
Fibrosis
Heart
Heart atria
Heart Atria - pathology
Heart Atria - radiation effects
Heart Atria - ultrastructure
Irradiation
Lesions
Microscopy, Electron
Myocardium - pathology
Necrosis
Pathology
Pericardial Effusion - etiology
Pericardial Effusion - pathology
Rabbits
Radiation Dosage
Radiotherapy
X-Rays
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Summary:Ten dogs received a single exposure of 10 MeV X rays to the heart. Five dogs received 1500 rad to the midline and five received 1000 rad. When the dogs expired or were killed 73-85 days after irradiation, their hearts were examined pathologically. The changes most frequently observed were pericardial effusion and in the right atrium, myocardial necrosis, and fibrosis. The data suggest that under the conditions of this experiment, irradiation of the canine heart causes greatest damage to the right atrium.
ISSN:0033-7587
1938-5404
DOI:10.2307/3575248